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[Myocardial revascularization in the developing phase of myocardial infarction using intracoronary thrombolytic
Insights
Intracoronary thrombolysis using streptokinase achieved early reperfusion in 66% of myocardial infarction patients. This treatment showed no acute mortality, but had a 17% reocclusion rate.
Area of Science:
- Cardiology
- Interventional Cardiology
Context:
- Myocardial infarction (MI) treatment
- Acute coronary syndrome management
Purpose:
- Evaluate intracoronary thrombolysis efficacy and safety
- Assess reperfusion rates and outcomes in MI patients
Summary:
- Study involved 71 patients with acute myocardial infarction undergoing coronary angiography within 6 hours.
- Intracoronary administration of isosorbide dinitrate and streptokinase.
- Achieved early reperfusion in 66% of patients, with no acute mortality.
- ST-segment normalization in 41/47 reperfused cases; Q wave development in 42 cases.
- Hospital mortality was 6.4%, and reocclusion rate was 17%.
Impact:
- Demonstrates feasibility of intracoronary thrombolysis for acute MI.
- Highlights reperfusion benefits and potential complications.
- Provides data on treatment outcomes and long-term considerations.
Abstract:
The author's experience on intracoronary thrombolysis on 71 patients that underwent coronary angiography in the first six hours of myocardial infarction is presented. The coronary artery responsible for the infarction was totally occluded in 66 cases and presented a subtotal occlusion in the remaining 5 cases. The protocol included the intracoronary injection of 2 mg isosorbide dinitrate and 78.000-385.000 U of streptokinase. An early reperfusion occurred in 66% of the patients, without mortality in the acute phase. ST-segment returned to normal in 41 of the 47 reperfused cases, but a Q wave developed in 42 cases. Hospital mortality was 6,4%, and the reocclusion rate was 17%.