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[Changes in blood lipoproteins in patients with peripheral atherosclerosis after hemosorption]
Insights
Extracorporeal haemosorption temporarily lowers blood lipids in peripheral atherosclerosis patients. Post-treatment, high-density lipoprotein cholesterol levels significantly increase, potentially improving clinical outcomes.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Medical Technology
Context:
- Obliterating peripheric atherosclerosis is characterized by elevated cholesterol and triglycerides.
- Patients exhibit lower high-density lipoprotein (HDL) cholesterol levels compared to controls.
- HDL cholesterol inversely correlates with disease severity.
Purpose:
- To investigate the effects of extracorporeal haemosorption on lipid profiles in peripheral atherosclerosis.
- To evaluate changes in lipoprotein concentrations, including HDL cholesterol, after treatment.
- To explore the relationship between observed alterations and clinical outcomes.
Summary:
- Extracorporeal haemosorption using activated charcoal and heparin reduced cholesterol, triglycerides, and lipoprotein levels in patients.
- While initial lipid levels returned to baseline, HDL cholesterol significantly increased by 39% within 7-14 days post-treatment.
- Polyacrylamide gel disc electrophoresis confirmed these HDL alterations.
Impact:
- The observed increase in HDL cholesterol may contribute to the favorable clinical effects of haemosorption in peripheral atherosclerosis.
- These findings suggest haemosorption influences lipid metabolism and lipoprotein dynamics.
- Further research is needed to elucidate the mechanisms behind the sustained HDL increase.
Abstract:
Concentrations of cholesterol, triglycerides and the molar ratio cholesterol/phospholipids were higher while the values of cholesterol in high density lipoproteins (HDL) was lower in blood of patients with obliterating peripheric atherosclerosis as compared with control values. After extracorporal haemosorption on columns with activated charcoal and preadministration of heparin all the patterns studied were decreased, thus indicating the sorption of all the lipoprotein classes, including anti-atherogenic HDL, simultaneously with lipolysis of very low density lipoproteins, triglycerides as well as the sorption and destruction of large erythrocytes containing relatively high amount of cholesterol. Within the subsequent period all the patterns studied returned to the initial level. At the same time, concentration of HDL cholesterol, which, as shown earlier, correlated inversely with severity of clinical manifestations in the patients, continued to increase, exceeding the initial level by 39% within 7-14 days; these data were also corroborated by polyacrylamide gel disc electrophoresis. The alterations found may be among the factors, responsible for favourable clinical effect of haemosorption in the patients with peripheric atherosclerosis. Possible reasons for the HDL concentration increase are discussed.