Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal methods for evaluating therapy.

J D Clemens, R I Horwitz

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Environmental reservoirs of Vibrio cholerae.

    Vaccine·2019
    Same author

    How deceptive are microstructures in granitic rocks? Answers from integrated physical theory, phase equilibrium, and direct observations.

    Contributions to mineralogy and petrology. Beitrage zur Mineralogie und Petrologie·2019
    Same author

    The public health significance of latrines discharging to groundwater used for drinking.

    Water research·2017
    Same author

    Gender difference in prognosis after transient cerebral ischemia or minor stroke.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Peru-15 (Choleragarde(®)), a live attenuated oral cholera vaccine, is safe and immunogenic in human immunodeficiency virus (HIV)-seropositive adults in Thailand.

    Vaccine·2015
    Same author

    Risk factors associated with typhoid fever in children aged 2-16 years in Karachi, Pakistan.

    Epidemiology and infection·2011
    Same journal

    Corrigendum to 'A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis)' [Biomed. Pharmacother. 181 (2024) 117706].

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Comparative in vitro evaluation of fourth-generation anti-GPC3 CAR T-cells in hepatocellular carcinoma.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Inhibition of the ZEB1-BCL2 axis in cancer-associated fibroblasts as a strategy to improve chemotherapy response in intrahepatic cholangiocarcinoma.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    From DNA-encoded library (DEL) screening to in vivo validation: LILRB4 (ILT3)-targeted small molecules reprograms myeloid immune suppression.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    See all related articles

    Longitudinal studies offer robust evidence by separating cause and effect in therapy outcomes. However, their limitations necessitate developing alternative methods for assessing therapeutic effectiveness, especially for rare or delayed outcomes.

    Area of Science:

    • Clinical research methodology
    • Therapeutic outcome assessment

    Background:

    • Longitudinal studies excel at establishing causality in therapy by controlling for confounding factors.
    • They allow for the incorporation of follow-up duration and prevent biases from non-concurrent treatments or unequal patient characteristics.

    Purpose of the Study:

    • To highlight the strengths of longitudinal studies in evaluating therapeutic effectiveness.
    • To identify the limitations of longitudinal studies and clinical trials in specific therapeutic contexts.
    • To underscore the need for alternative research methods.

    Main Methods:

    • The study reviews the inherent advantages of longitudinal study designs in clinical research.
    • It analyzes the limitations related to rare outcomes, long latency periods, and logistical/ethical constraints of clinical trials.

    Related Experiment Videos

  • The abstract discusses the implications for therapeutic research, particularly for preventive therapies.

    • Main Results:

    • Longitudinal studies provide strong evidence for cause-effect relationships in therapy.
    • Limitations include challenges in studying rare or late-onset outcomes and practical constraints in randomized trials.
    • These limitations restrict their applicability for certain research questions, especially in preventive medicine.

    Conclusions:

    • Longitudinal studies are valuable for assessing therapeutic outcomes when causality is key.
    • Alternative methods are crucial for addressing therapeutic questions where longitudinal or randomized trial designs are infeasible or unethical.
    • Further research is needed to develop and validate these alternative assessment methods.