[Derivatives of N-hydroxyfenfluramine and their anorectic activity]

Some derivatives of N-hydroxyfenfluramine substituted at the oxygen atom with benzyl, N-methylcarbamoyl, aliphatic and aromatic acyl groups, were prepared and the anorectic activity was investigated in the rat in comparison with fenfluramine. The most interesting compound was N-(2,6-dimethoxybenzoyloxy)fenfluramine (XIV), which exhibited a LD50 about 5 times higher than that of fenfluramine and a remarkably delayed activity.