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Updated: Sep 1, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Simulation of pharmacokinetic behaviour of drug-cyclodextrin complexes
Abstract:
Complexation with cyclodextrin decreases the hydrophobicity of poorly soluble drugs and results in enhanced dissolution rates and higher solubility. In vivo experiments showed that this "molecular encapsulation" of drugs leads to enhanced bioavailability, which is controlled by the solubilities, stability constants of the complexes, the molar ratio of drug: cyclodextrin, etc. This modification of the pharmacokinetic processes has been simulated by computing the theoretical blood level curves. These computer-simulated curves seem to be appropriate models of the experimental observations. Knowing the numerical values of the parameters utilized in these computer simulations, the modification of the pharmacokinetics can be predicted when using cyclodextrin complexes in oral dosage forms.
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