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Related Experiment Videos

[The recessive Hm phenotypes].

M Hrubisko, F Klinda, V Krislo

    Revue Francaise De Transfusion Et Immuno-Hematologie
    |February 1, 1978
    PubMed
    Summary
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    Bombay and para Bombay red cell phenotypes reveal complex ABH antigen formation. Recessive H deficiency arises from regulatory gene non-activity, not an amorphic h gene.

    Area of Science:

    • Immunogenetics
    • Hematology
    • Biochemistry

    Context:

    • Investigating the survival of Bombay and para Bombay erythrocytes.
    • Examining red cells within non-compatible and para Bombay individuals.
    • Addressing the heterogeneity of these blood group phenotypes.

    Purpose:

    • To elucidate the genetic basis of H deficient recessive phenotypes.
    • To understand the role of regulatory genes (x and z alleles) in H gene function.
    • To propose new nomenclature for Bombay (Hxx) and para Bombay (Hzz) phenotypes.

    Summary:

    • The study demonstrates heterogeneity in Bombay and para Bombay phenotypes, indicating highly differentiated ABH antigens.
    • H deficient recessive phenotypes are attributed to the non-activity of regulatory genes (xx or zz alleles), impacting H gene function.

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  • The genetics and synthesis of Ah, Bh (AHm, BHm) phenotypes remain unclear, suggesting potential interactions between zz and sese genes or trans-complementation.

    • Impact:

    • Proposes a new genetic model for H deficiency, moving beyond the amorphic h gene concept.
    • Introduces novel nomenclature (Hxx, Hzz) for improved classification of these rare blood groups.
    • Highlights areas for future research into complex gene interactions governing ABH antigen expression.