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Related Experiment Videos

Rosetting index (E rosettes/mouse rosettes): a simple diagnostic and prognostic value in CLL.

A Berrebi, M Talmor, Y Kluger

    Haematologia
    |January 1, 1984
    PubMed
    Summary

    The rosetting index aids in characterizing B-cell chronic lymphocytic leukemia (B-CLL) across all stages. Its decrease correlates with disease activity, suggesting prognostic value, while elevated levels help differentiate T-cell CLL and benign lymphocytosis.

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    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Chronic lymphocytic leukemia (CLL) diagnosis and staging are critical for patient management.
    • The rosetting index, a measure of E rosettes (T-cell rosettes with erythrocytes), has been explored for its diagnostic and prognostic utility.

    Purpose of the Study:

    • To evaluate the rosetting index for characterizing B-cell chronic lymphocytic leukemia (B-CLL) in various stages.
    • To assess the rosetting index's potential as a prognostic factor in B-CLL.
    • To differentiate B-CLL from T-cell CLL and chronic benign T lymphocytosis.

    Main Methods:

    • The rosetting index was measured in 34 controls, 4 chronic benign lymphocytosis patients, and 28 CLL patients classified by Rai stage.
    • Statistical analysis using Student's t-test was performed to compare rosetting index values between groups.

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    Main Results:

    • The rosetting index decreased progressively with increasing Rai stage in B-CLL patients (Stage 0: 0.35 ± 0.2; Stage 1-2: 0.19 ± 0.11; Stage 3-4: 0.09 ± 0.09).
    • A significant difference was observed between controls (average 10.0) and B-CLL patients (p < 0.0001).
    • The rosetting index was significantly elevated in T-cell CLL and chronic benign T lymphocytosis (25 ± 15) compared to B-CLL, aiding differentiation.

    Conclusions:

    • The rosetting index is a valuable tool for characterizing B-CLL across all disease stages.
    • A decreasing rosetting index correlates with increased disease proliferative activity, indicating its potential as a prognostic marker.
    • Elevated rosetting index values are useful in distinguishing T-cell CLL and chronic benign T lymphocytosis from early-stage B-CLL, especially when surface immunoglobulin (SmIg) results are inconclusive.