[Cervical intraepithelial neoplasms and flat condylomata. Study of 165 cases]

205 cervix biopsies and diagnostic conisations performed among 165 women with dysplasias and carcinomas in situ (CIS) where revised with actual concepts of flat condylomata (FC) and cervical intraepithelial neoplasias (CIN). Usual statistical tests were used to analyse the signification of the average age of the different group (FC alone, FC + CIN, CIN alone) and according to the different grades of CIN. The association between FC and the different grades of CIN was studied with the X2 test. In 66.8% of the cases, FC was present, associated or not with CIN. That ends up to a modification of the diagnosis in 37.6% of the cases (reduction of a grade of CIN, substitution of a mild dysplasia CIN I by a FC). In 33.8% of the cases, FC was associated with CIN. In this work, the average age between CIN associated with FC was 8 years less than CIN alone. The X2 test applied to the frequency of association between FC and CIN according to the grade of CIN have shown that it exists a statistically valid difference between the grades. More the grades is high, more the morphological characters of the FC are rare. These observations suggest an integration of the viral genome in the host genome as it has been proved for the shope papilloma and the verruciformis epidermodysplasia.