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Prophylactic intravenous metronidazole in cesarean section.
Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|February 1, 1984
Summary
This study found intravenous metronidazole effective for preventing fever and wound infections after cesarean sections. A single 500 mg dose proved satisfactory for prophylactic chemotherapy in obstetric patients.
Area of Science:
- Obstetrics and Gynecology
- Infectious Disease Prevention
- Pharmacology
Background:
- Cesarean sections carry risks of febrile morbidity and surgical site infections.
- Prophylactic chemotherapy is a strategy to mitigate these postoperative complications.
Purpose of the Study:
- To compare the efficacy of ampicillin versus intravenous metronidazole in preventing febrile morbidity and wound sepsis following cesarean section.
- To evaluate the optimal dosage regimen for prophylactic metronidazole in this patient population.
Main Methods:
- A prospective study involving 100 patients undergoing cesarean section.
- Patients were randomized to receive either ampicillin or intravenous metronidazole.
- Metronidazole was administered in single (500 mg) or multiple doses.
Main Results:
- The overall febrile morbidity rate was 20%.
- Intravenous metronidazole demonstrated superior efficacy in reducing febrile morbidity compared to ampicillin (P < 0.05).
- Metronidazole also significantly reduced the incidence of wound sepsis.
Conclusions:
- Prophylactic chemotherapy is beneficial for obstetric patients undergoing cesarean section.
- Intravenous metronidazole is an effective agent for preventing postoperative complications.
- A single intravenous dose of 500 mg metronidazole is sufficient for prophylactic use in cesarean section patients.