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Plasma serotonin concentrations during and after cardiac surgery
European Journal of Anaesthesiology
|March 1, 1984
Summary
Plasma serotonin (5-hydroxyindoles) levels did not change during heart surgery bypass. Researchers found no link between plasma 5-hydroxyindoles and postoperative hypertension in cardiac surgery patients.
Area of Science:
- Cardiovascular Surgery
- Neuropharmacology
- Biochemistry
Background:
- Serotonin (5-hydroxytryptamine, 5-HT) plays a role in various physiological processes.
- Its involvement in postoperative hypertension following cardiac surgery is not fully understood.
- Plasma 5-hydroxyindoles (5-HI) and platelet 5-HT are key indicators of serotonin activity.
Purpose of the Study:
- To investigate the role of plasma serotonin concentrations in postoperative hypertension after myocardial revascularization.
- To measure plasma 5-hydroxyindoles (5-HI) and platelet 5-hydroxytryptamine (5-HT) in patients undergoing cardiac surgery.
Main Methods:
- Assayed plasma 5-HI and platelet 5-HT in 12 coronary artery graft surgery patients and 5 valve replacement patients.
- Measured concentrations before, during, and after cardiopulmonary bypass (CPB).
- Correlated plasma 5-HI levels with systolic blood pressure postoperatively.
Main Results:
- Plasma 5-HI concentrations remained stable throughout CPB and postoperatively in both groups.
- No significant correlation was observed between plasma 5-HI levels and postoperative hypertension.
- Platelet 5-HT significantly increased during bypass but returned to baseline levels afterward.
Conclusions:
- Plasma 5-HI concentrations are unlikely to be a significant factor in the pathophysiology of postoperative hypertension after myocardial revascularization.
- Platelet 5-HT levels fluctuate during CPB but normalize postoperatively.