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Human neuron-specific enolase: genetic and developmental studies.

S H Chen, G S Omenn

    Journal of Neurogenetics
    |April 1, 1984
    PubMed
    Summary
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    Neuron-specific enolase is detectable in human fetal brains by 54 days gestation. This enzyme increases with nervous system development, and no genetic variants were found, indicating highly restricted variation.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • Neuron-specific enolase (NSE) is a key glycolytic enzyme.
    • NSE plays a crucial role in neuronal energy metabolism.
    • Understanding NSE's developmental expression is vital for neuroscience research.

    Purpose of the Study:

    • To investigate the early detection and developmental trajectory of Neuron-specific enolase (NSE) in the human fetal nervous system.
    • To analyze the genetic variability of NSE in fetal and postnatal human specimens.

    Main Methods:

    • Analysis of human fetal brain extracts.
    • Assessment of Neuron-specific enolase (NSE) levels during development.
    • Genetic sequencing of 14 fetal and 120 postnatal specimens to identify enzyme variants.

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    Main Results:

    • Neuron-specific enolase (NSE) was detected as early as 54 days of gestational age in human fetal brain tissue.
    • NSE levels demonstrated a rapid increase correlating with the developmental maturation of the nervous system.
    • No genetic variants of the Neuron-specific enolase (NSE) enzyme were identified in any of the analyzed specimens.

    Conclusions:

    • Neuron-specific enolase (NSE) is an early marker of human nervous system development.
    • The high conservation of NSE suggests a critical, conserved function in neuronal metabolism.
    • Further research can utilize NSE as a biomarker for neurodevelopmental studies.