Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Granulocyte function in Duchenne's progressive muscular dystrophy].

C Adami Lami, A Bruni, G Forgeschi

    Quaderni Sclavo Di Diagnostica Clinica E Di Laboratorio
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

    Physical review letters·2026
    Same author

    Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Locally advanced NSCLC: overview of real-world pattern of recurrence in durvalumab era (LEOPARD trial).

    Lung cancer (Amsterdam, Netherlands)·2025
    Same author

    Translational insights into diet consistency, masticatory efficiency, and posterior crossbite: potential implications for craniofacial development and general health.

    European journal of paediatric dentistry·2025
    Same author

    Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same journal

    [Evaluation of the specific immune response after anti-rubella vaccination].

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    Same journal

    [Automatic tracing of conversion scales from conventional units to the SI system of units].

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    Same journal

    [Circadian rhythm of human lymphocyte subpopulations].

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    Same journal

    [Comparison between 2 separation methods of IgM and IgG in serologic diagnosis].

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    Same journal

    [Semiautomatic procedure for determining urine iron in subjects treated with deferoxamine B].

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    Same journal

    Relation between fasting C-peptide and other clinical and metabolic variables in non-insulin-dependent diabetes mellitus.

    Quaderni Sclavo di diagnostica clinica e di laboratorio·1988
    See all related articles

    Polymorphonuclear leukocytes show reduced movement in Duchenne muscular dystrophy patients. This immune cell dysfunction may stem from muscular and cellular changes, indicating a systemic membrane disease.

    Area of Science:

    • Immunology
    • Cellular Biology
    • Genetics

    Context:

    • Duchenne muscular dystrophy (DMD) is a severe genetic disorder affecting muscle fibers.
    • Investigating the role of immune cells in DMD pathogenesis is crucial for understanding disease progression.
    • Polymorphonuclear leukocytes (PMNs) are key immune cells involved in inflammation and pathogen defense.

    Purpose:

    • To investigate the in vitro function of polymorphonuclear leukocytes (PMNs) in patients with Duchenne muscular dystrophy.
    • To assess PMN chemotaxis and bactericidal activity in relation to DMD.
    • To explore potential links between PMN dysfunction and the underlying pathophysiology of DMD.

    Summary:

    • This study examined polymorphonuclear leukocyte (PMN) function in 14 pediatric patients (2-14 years) with Duchenne muscular dystrophy.

    Related Experiment Videos

  • Results indicated significantly reduced PMN chemotaxis (cell movement) in DMD patients.
  • PMN bactericidal activity showed variable results, being sometimes reduced and sometimes increased, suggesting complex immune alterations.

    • Impact:

    • Findings suggest PMN dysfunction, particularly impaired motility, is a feature of Duchenne muscular dystrophy.
    • This immune cell alteration may be linked to muscular apparatus changes and electrolytic imbalances.
    • The study supports the view of DMD as a systemic membrane disease affecting various cells and tissues beyond muscle fibers.