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Cerebrovascular complications associated with idiopathic hypertrophic subaortic stenosis
Insights
Idiopathic hypertrophic subaortic stenosis (IHSS) patients rarely present with stroke, and the long-term risk is generally low. However, atrial fibrillation and mitral annulus calcification significantly increase stroke risk in these individuals.
Area of Science:
- Cardiology
- Neurology
- Vascular Medicine
Background:
- Idiopathic hypertrophic subaortic stenosis (IHSS) is a cardiovascular condition.
- Cerebrovascular complications are a potential concern in patients with IHSS.
Purpose of the Study:
- To evaluate the incidence and risk factors of cerebrovascular complications in patients with IHSS.
- To assess the long-term prognosis regarding stroke in IHSS patients.
Main Methods:
- A follow-up study of 150 patients diagnosed with IHSS.
- Average follow-up duration of 5.5 years.
- Data collected on patient demographics, presenting symptoms, cardiac events, and cerebrovascular complications.
Main Results:
- No patient presented with stroke; cardiac symptoms or syncope were common.
- Eight patients (5%) died from cardiac causes during follow-up.
- Eleven patients (7%) experienced cerebrovascular events (5% stroke, 4% TIA).
- Atrial fibrillation and mitral annulus calcification were identified as risk factors for stroke.
Conclusions:
- Stroke is an uncommon presenting manifestation and long-term risk for most IHSS patients.
- Patients with IHSS and atrial fibrillation face a significantly elevated stroke risk.
- Mitral annulus calcification may also contribute to increased stroke risk in this population.
Abstract:
One hundred fifty patients with idiopathic hypertrophic subaortic stenosis (IHSS) were followed-up for an average of 5.5 years. There were 95 males and 55 females with a mean age of 51 years. Patients usually presented with cardiac symptoms or syncope; no patient presented with stroke. Eight patients (5%) died during follow-up, all from cardiac causes. Eleven patients (7%) developed cerebrovascular complications; 5 (3%) had a stroke and 6 (4%) had TIA only. Patients with IHSS and atrial fibrillation have a much greater stroke risk. Mitral annulus calcification may also increase stroke risk in IHSS. However, stroke is almost never the presenting manifestation of IHSS, and the longterm risk of stroke for most patients with known IHSS is low.