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Genetic and cytogenetic effects of Fenitrothion
Archives of Environmental Health
|January 1, 1984
Abstract:
Male mice (Q strain) were injected intraperitoneally with a high dose (i.e., 1 g/kg) of the organophosphorus insecticide Fenitrothion. No increase in the percentage of chromosome aberrations was observed in bone marrow cells and spermatogonia. A dominant lethal mutation assay did not show any enhancement of fetal mortality before or after implantation.
Insights
High-dose Fenitrothion insecticide did not increase chromosome damage in male mice. A dominant lethal mutation assay also found no evidence of increased fetal mortality, suggesting low genotoxic risk.
Area of Science:
- Toxicology
- Genetics
- Environmental Science
Background:
- Organophosphorus insecticides are widely used pesticides.
- Fenitrothion is a common organophosphate insecticide.
- Assessing insecticide genotoxicity is crucial for environmental and human health risk evaluation.
Purpose of the Study:
- To evaluate the genotoxic potential of Fenitrothion in male mice.
- To determine if Fenitrothion induces chromosome aberrations.
- To assess the dominant lethal mutation effects of Fenitrothion.
Main Methods:
- Male mice (Q strain) were administered a high dose (1 g/kg) of Fenitrothion intraperitoneally.
- Bone marrow cells and spermatogonia were analyzed for chromosome aberrations.
- A dominant lethal mutation assay was conducted to evaluate fetal mortality.
Main Results:
- No significant increase in chromosome aberrations was observed in bone marrow cells.
- No significant increase in chromosome aberrations was observed in spermatogonia.
- The dominant lethal mutation assay showed no enhancement of fetal mortality.
Conclusions:
- Fenitrothion, at the tested high dose, did not induce significant genotoxicity in male mice.
- The insecticide did not cause chromosome damage or increase fetal mortality.
- These findings suggest a low risk of genotoxicity from Fenitrothion exposure in this model.