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Plasma prolactin and severe premenstrual tension
Psychoneuroendocrinology
|January 1, 1984
Summary
This study found no direct link between prolactin (PRL) levels and premenstrual tension syndrome (PMTS) symptoms. Research indicates that prolactin fluctuations do not cause or correlate with PMTS in women.
Area of Science:
- Reproductive Endocrinology
- Neuroendocrinology
Background:
- Elevated prolactin (PRL) levels have been hypothesized to contribute to premenstrual tension syndrome (PMTS) symptoms.
- Understanding the hormonal basis of PMTS is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the potential relationship between serum prolactin levels and the severity of premenstrual tension syndrome (PMTS).
- To assess the impact of bromocriptine treatment on prolactin levels and PMTS symptoms.
Main Methods:
- Serum prolactin levels were measured in 37 women with severe PMTS during the follicular and luteal phases.
- 24-hour prolactin profiles were recorded in a subset of patients and controls.
- A treatment trial with bromocriptine was conducted in 30 subjects.
Main Results:
- Mean prolactin levels were within the normal range for all participants.
- A slight premenstrual increase in afternoon prolactin was observed but lacked clear significance.
- Bromocriptine cessation led to rebound hyperprolactinemia without affecting mood or menstrual regularity.
Conclusions:
- The study data do not support a specific relationship between prolactin levels and premenstrual tension syndrome.
- Further research may be needed to explore other potential hormonal or neurobiological factors in PMTS.