[Histological evaluation of cancer chemotherapy on rat ovarian cancer]

To evaluate the effect of cis-diamminedichloroplatinum (DDP), the drug-induced changes of tumor tissue were observed morphologically on a primary ovarian cancer in rat. In order to avoid artificial damages of the tissue, trans-aortic perfused fixation was demanded for light microscopy. The results obtained were as follows; 1) various degrees of cancer cell damages, presumably caused from different sensitivities of the each cell and vascularization, were observed 2) vascular networks were affected to decrease by the cytotoxic agent 3) the tumor size was occasionally decided by a proliferation of connective tissues in which survived cancer cells were found 4) an increase of histiocytes played a notable role to sweep out the damaged cells. A histologic examination at second look surgery in a clinical case reflected these results.