Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic and inflammatory responses during pregnancy.

D Holland, P Bretscher, A S Russell

    Journal of Clinical & Laboratory Immunology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Commentary on: Inspiratory Muscle Training, with or without Pulmonary Rehabilitation, for COPD: A Critical Appraisal of a Cochrane Review.

    Journal of the Association of Chartered Physiotherapists in Respiratory Care·2025
    Same author

    Framework for classifying chemicals for repeat dose toxicity using NAMs.

    Archives of toxicology·2025
    Same author

    Boron coordination change in barium borate melts and glasses and its contribution to configurational heat capacity, entropy, and fragility.

    The Journal of chemical physics·2023
    Same author

    Correction to: PANLAR consensus statement on biosimilars.

    Clinical rheumatology·2019
    Same author

    PANLAR consensus statement on biosimilars.

    Clinical rheumatology·2019
    Same author

    Factors Affecting the Response of Pomegranate Fruit to Alternaria alternata, the Causal Agent of Heart Rot.

    Plant disease·2018
    Same journal

    Policy and science of FMD control: the stakeholders' contribution to decision making. A call for integrated animal disease management.

    Journal of clinical & laboratory immunology·2006
    Same journal

    An informative case of Graves' disease with implications for schizophrenia.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Review: immunomodulatory activity of pregnancy-associated plasma protein-A.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante-mortem test.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy.

    Journal of clinical & laboratory immunology·2004
    See all related articles

    Pregnancy does not reduce the immune response in mice, but it does impair the initial phase of certain immune reactions. Further research is needed to link these findings to rheumatoid arthritis remission during pregnancy.

    Area of Science:

    • Immunology
    • Reproductive Immunology
    • Inflammation Research

    Background:

    • Rheumatoid arthritis often improves during pregnancy.
    • This improvement is hypothesized to stem from reduced immune or inflammatory activity.
    • Investigating pregnancy's impact on immune responses is crucial for understanding this phenomenon.

    Purpose of the Study:

    • To investigate the effect of pregnancy on delayed type hypersensitivity (DTH) responses in a murine model.
    • To determine if pregnancy alters immune effector mechanisms relevant to rheumatoid arthritis remission.

    Main Methods:

    • Elicited DTH response to Burro RBC in pregnant and non-pregnant mice.
    • Administered carrageenan to assess non-immunologic inflammatory response.
    • Measured footpad swelling as an indicator of inflammatory response.

    Related Experiment Videos

    Main Results:

    • No significant difference in DTH swelling was observed between pregnant and control mice.
    • The response to carrageenan, a non-immunologic stimulus, was not decreased in pregnant mice.
    • A defect in the priming or induction phase of a primary DTH response was observed in pregnant mice.

    Conclusions:

    • Pregnancy did not attenuate established immune effector mechanisms in this model.
    • Pregnancy impaired the induction phase of a primary DTH response.
    • The relevance of this impaired induction phase to pregnancy-induced rheumatoid arthritis remission requires further investigation.