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Brainstem responses in the quivering mutant mouse.

G R Bock, M P Frank

    Acta Oto-Laryngologica
    |September 1, 1984
    PubMed
    Summary
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    The quivering gene in mice causes neurological issues and deafness. Auditory nerve input to the cochlear nucleus appears normal, but central processing deficits are evident in the cochlear nucleus of quivering mice.

    Area of Science:

    • Neuroscience
    • Genetics
    • Auditory Neuroscience

    Background:

    • The recessive quivering gene (qv/qv) in mice leads to neurological abnormalities and deafness.
    • Previous studies showed normal cochlear responses but abnormal inferior colliculus evoked potentials in quivering mice.

    Purpose of the Study:

    • To investigate auditory processing at the cochlear nucleus (CN) level in quivering mice.
    • To compare CN evoked potentials and surface responses between quivering and control mice.

    Main Methods:

    • Recording evoked potentials from the cochlear nucleus (CN) in quivering (qv/qv) and control mice.
    • Recording surface responses in both groups of mice.

    Main Results:

    • The first peak of the CN evoked response was normal in quivering mice, indicating normal auditory nerve input.

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  • The second peak of the CN evoked response was smaller and had longer latency in quivering mice.
  • Surface responses in quivering mice showed an abnormal wave pattern after the initial normal wave.

    • Conclusions:

    • Auditory nerve input to the cochlear nucleus is likely normal in quivering mice.
    • The central auditory processing deficit in quivering mice is localized to the cochlear nucleus level.