Related Experiment Video

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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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["Moyamoya" disease]

E I Zlotnik, V F Kuznetsov, Z M Kastritskaia

    Voprosy Neirokhirurgii
    |March 1, 1978
    PubMed

    Insights

    Moyamoya disease, a rare cerebrovascular condition, presents varied clinical features in adults, including ischemic attacks and intracerebral hemorrhages. Early diagnosis and treatment are crucial for managing this condition.

    Area of Science:

    • Neurology
    • Vascular Neurology
    • Neuroimaging

    Background:

    • Moyamoya disease is a rare, progressive cerebrovascular disorder characterized by stenosis of the terminal internal carotid arteries and the development of collateral circulation at the base of the brain.
    • The condition can lead to ischemic events, such as transient ischemic attacks (TIAs) and strokes, or hemorrhagic events, including intracerebral hemorrhage and subarachnoid hemorrhage.

    Observation:

    • This article describes six adult cases of moyamoya disease, highlighting the diverse clinical presentations.
    • Observations include ischemic attacks, intracerebral hematomas requiring surgical evacuation in two young females, and a case where the vascular anomaly manifested after craniocerebral trauma with subarachnoid hemorrhage and infarction.

    Findings:

    • The study details the clinical picture, diagnostic approaches, and treatment strategies for moyamoya disease in an adult cohort.
    • Findings underscore the variability in moyamoya disease presentation, ranging from ischemic to hemorrhagic events, and its potential association with head trauma.

    Implications:

    • Understanding the varied clinical spectrum of moyamoya disease is essential for timely diagnosis and appropriate management in adult patients.
    • This case series emphasizes the importance of considering moyamoya disease in patients presenting with unexplained neurological deficits, particularly ischemic or hemorrhagic events, and its potential link to head trauma.

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