[Antiemetic activity of dimetpramid]

It has been shown that dimethpramide, a new Soviet-made antiemetic belonging to the group of substituted benzamides, effectively prevents the emetic action of L-DOPA and apomorphine in dogs (the ED50 is 0.04 and 0.12 mg/kg, respectively). When given in doses of 10-25 mg/kg dimethpramide suppresses vomiting induced by adrenaline, histamine, strophanthine, sodium salicylate, and copper sulfate. The drug exerts a selective dopamine-blocking action on the receptors of the triggering zone of the vomiting center without producing any substantial action on the dopaminergic brain systems that regulate behavioral activity.