Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular permeability in acute hypertension.

G Olivetti, K Kithier, F Giacomelli

    Applied Pathology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adherence to Daily Oral TDF/FTC for PrEP in Community Health Center Populations: The Sustainable Health Center Implementation PrEP Pilot (SHIPP) Study.

    AIDS and behavior·2021
    Same author

    Automated Cerebral Hemorrhage Detection Using RAPID.

    AJNR. American journal of neuroradiology·2020
    Same author

    On the use of positron counting for radio-Assay in nuclear pharmaceutical production.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017
    Same author

    A new approach to immunologic identification of factor VIII antibodies.

    Haemophilia : the official journal of the World Federation of Hemophilia·2016
    Same author

    Automated production at the curie level of no-carrier-added 6-[(18)F]fluoro-L-dopa and 2-[(18)F]fluoro-L-tyrosine on a FASTlab synthesizer.

    Journal of labelled compounds & radiopharmaceuticals·2015
    Same author

    Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same journal

    Xanthomatous endometritis.

    Applied pathology·1989
    Same journal

    Pulmonary lymphangiomyomatosis. Report of a case with immunohistochemical and ultrastructural findings.

    Applied pathology·1989
    Same journal

    Endomandibular acinic cell carcinoma.

    Applied pathology·1989
    Same journal

    Cystadenofibroma of fallopian tube.

    Applied pathology·1989
    Same journal

    Plasma platelet factor 4 response in rhesus monkeys fed coconut oil.

    Applied pathology·1989
    Same journal

    Assessment of labial salivary gland changes in patients with rheumatoid arthritis by subjective and quantitative methods.

    Applied pathology·1989
    See all related articles

    Acute hypertension from angiotensin II (AII) infusion increases protein leakage in kidneys. This suggests AII may alter glomerular filter pores, impacting kidney function and protein filtration.

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Hypertension Research

    Background:

    • Hypertension is a major risk factor for kidney disease.
    • Angiotensin II (AII) plays a key role in regulating blood pressure.
    • The effects of acute hypertension on glomerular permeability are not fully understood.

    Purpose of the Study:

    • To investigate the impact of acute angiotensin II-induced hypertension on glomerular permeability.
    • To assess changes in the transglomerular passage of macromolecules.
    • To evaluate functional changes in glomerular filtration rate and clearance.

    Main Methods:

    • Intravenous infusion of angiotensin II (AII) to induce acute hypertension in a model system.
    • Electronmicroscopic immunoperoxidase techniques to visualize macromolecule passage.

    Related Experiment Videos

  • Quantitative measurements of albumin, IgG2a, and ferritin clearances.
  • Assessment of glomerular filtration rate (GFR) and p-aminohippurate (PAH) clearance.

    • Main Results:

    • Significant increase in transglomerular passage of albumin and IgG without morphological capillary damage.
    • Elevated concentrations of native ferritin in the glomerular basement membrane (GBM).
    • Decreased glomerular filtration rate (42%) and p-aminohippurate clearance (63%).
    • Markedly increased clearances for albumin (90-fold) and IgG2a (15-fold).

    Conclusions:

    • Acute AII-induced hypertension enhances glomerular permeability to proteins.
    • Increased pore size of the glomerular filter is suggested, potentially due to high intracapillary pressure or direct AII action on GBM.
    • These findings highlight a mechanism by which hypertension can acutely impair kidney function.