Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rapid searches for complex patterns in biological molecules.

R M Abarbanel, P R Wieneke, E Mansfield

    Nucleic Acids Research
    |January 11, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bartonella in dogs and fleas from Tulancingo, Hidalgo, Mexico.

    Medical and veterinary entomology·2020
    Same author

    Prevalence of Bartonella sp. in United States military working dogs with infectious endocarditis: a retrospective case-control study.

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2019
    Same author

    Walking in the shoes of caregivers of children with obesity: supporting caregivers in paediatric weight management.

    Clinical obesity·2017
    Same author

    FDA oversight of laboratory-developed tests will facilitate adoption of pharmacogenetic testing into routine clinical care.

    Journal of clinical pharmacology·2015
    Same author

    Determination of the surface density of polyethylene glycol on gold nanoparticles by use of microscale thermogravimetric analysis.

    Analytical and bioanalytical chemistry·2015
    Same author

    Evaluating the thermal damage resistance of graphene/carbon nanotube hybrid composite coatings.

    Scientific reports·2014
    Same journal

    Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

    Nucleic acids research·2026
    Same journal

    Correction to 'Differentiable partition function calculation for RNA'.

    Nucleic acids research·2026
    Same journal

    Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

    Nucleic acids research·2026
    Same journal

    Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

    Nucleic acids research·2026
    Same journal

    Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

    Nucleic acids research·2026
    Same journal

    Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

    Nucleic acids research·2026
    See all related articles

    Searching for patterns in genetic data is challenging due to information redundancy. A new program, QUEST, enables rapid searching of DNA and protein databases for complex, ambiguous sequence patterns.

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Biological sequences (DNA, protein) contain intrinsic redundancy, complicating pattern identification.
    • Efficiently searching large genetic databases for specific patterns is a significant challenge in bioinformatics.

    Purpose of the Study:

    • To introduce QUEST, an interactive, self-documenting computer program designed for rapid pattern searching in biological sequence data.
    • To enable the identification of highly redundant consensus sequences and complex character patterns within large DNA and protein databases.

    Main Methods:

    • Development of QUEST, a program utilizing a concise, flexible language for pattern specification.
    • Implementation of algorithms for handling multiple levels of ambiguity and pattern arrangement in sequence queries.

    Related Experiment Videos

  • Application of QUEST to search large DNA and protein data banks.

    • Main Results:

    • QUEST facilitates rapid searching of extensive biological sequence data.
    • The program effectively identifies highly redundant consensus sequences and character patterns.
    • Demonstrated utility of QUEST through examples of its application to sequence data analysis.

    Conclusions:

    • QUEST provides an efficient solution for pattern discovery in redundant genetic information.
    • The program's flexible pattern language and optimized algorithms enhance the analysis of large biological sequence datasets.
    • QUEST is a valuable tool for researchers working with DNA and protein sequence data.