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Taste preference test for oral liquid theophylline preparations
American Journal of Hospital Pharmacy
|May 1, 1978
Summary
Male participants preferred Theophyl-225 Elixir over other theophylline oral liquids. Taste preference was statistically significant, with formulation and concentration influencing the results.
Area of Science:
- Pharmacology
- Pharmaceutical Sciences
- Clinical Pharmacy
Background:
- Theophylline is a widely used bronchodilator for respiratory conditions.
- Patient adherence to oral theophylline therapy can be affected by palatability.
- Evaluating taste preferences for different theophylline formulations is crucial for improving patient compliance.
Purpose of the Study:
- To assess and compare the taste preferences of three different oral liquid theophylline preparations among adult males.
- To identify potential factors influencing taste acceptance of theophylline formulations.
Main Methods:
- A taste preference study was conducted with 54 male participants.
- Three theophylline oral liquid preparations with varying concentrations were evaluated: Elixophyllin Pediatric Suspension (100 mg/5 ml), Somophyllin Oral Liquid (90 mg/5 ml), and Theophyl-225 Elixir (37.5 mg/5 ml).
- Standard taste testing procedures were employed to gather preference data.
Main Results:
- Theophyl-225 Elixir was the most preferred formulation.
- Elixophyllin Pediatric Suspension was the second most preferred.
- Somophyllin Oral Liquid received the lowest taste preference rating.
- Statistical analysis confirmed a significant difference in taste preferences (p = 0.05).
Conclusions:
- Theophyl-225 Elixir demonstrated superior palatability compared to the other tested theophylline preparations.
- Theophylline concentration and formulation characteristics significantly impact taste preferences.
- Findings suggest that formulation optimization can enhance the acceptability of oral theophylline medications.