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Squamous cells in the human thyroid gland.

V A LiVolsi, M J Merino

    The American Journal of Surgical Pathology
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Squamous epithelium in the thyroid can originate from developmental remnants or metaplasia of follicular cells. Malignant squamous thyroid neoplasms likely arise from metaplasia of follicular epithelium.

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    Area of Science:

    • Endocrinology
    • Surgical Pathology
    • Developmental Biology

    Background:

    • Squamous epithelium is an uncommon finding in the thyroid gland.
    • Its presence can be attributed to developmental remnants or cellular metaplasia.

    Purpose of the Study:

    • To elucidate the diverse origins of squamous epithelium within the thyroid gland.
    • To differentiate between developmental and metaplastic sources of squamous cells in thyroid tissues.

    Main Methods:

    • Histopathological examination of normal and diseased thyroid tissues.
    • Analysis of cellular morphology and tissue architecture.
    • Review of embryological development of the thyroid and related structures.

    Main Results:

    Related Experiment Videos

    • Normal thyroids may contain squamous cell nests from thymic or ultimobranchial remnants.
    • Thyroid cysts with squamous epithelium can result from thyroglossal duct anomalies.
    • In diseased thyroids, squamous or epidermoid epithelium often arises from metaplasia of follicular cells.
    • Malignant squamous thyroid tumors (adenoacanthoma, adenosquamous carcinoma, pure squamous carcinoma) are likely derived from metaplastic follicular epithelium undergoing malignant transformation.

    Conclusions:

    • Squamous epithelium in the thyroid has varied origins, including developmental remnants and follicular cell metaplasia.
    • Metaplasia of follicular cells is the predominant source in diseased thyroids and malignant neoplasms.
    • Understanding these origins is crucial for accurate diagnosis and classification of thyroid lesions.