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Updated: Aug 17, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Mechanisms for the control of body-weight
Abstract:
Various hypotheses for the mechanism of regulation of body-weight in human adults have been proposed in the light of the magnitude of the long-term changes in weight actually observed. One of these hypotheses has been represented in the form of a computer simulation model which has been used to demonstrate that (i) it is not necessary to postulate the existence of a set-point regulatory system, and (ii) in practice, several mechanisms, including hunger and satiety, the relative constancy of habits and customs of behaviour, and the existence of cognitive thresholds combined with a relatively simple physiological negative feedback system probably constitute the simplest hypothesis for the mechanism of weight stability.
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