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Updated: Aug 7, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Insights
Fever in infants under 24 months requires careful evaluation for serious bacterial infections. This clinical approach helps avoid misdiagnosis and unnecessary testing in young children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Clinical Medicine
Background:
- Fever in infants under 24 months is a common clinical challenge.
- The presence of fever raises concern for serious bacterial infections (SBIs).
- Accurate diagnosis is crucial to prevent under- or overtreatment.
Purpose of the Study:
- To provide a structured clinical approach for evaluating fever in infants.
- To guide practitioners in identifying infants with SBIs.
- To minimize excessive diagnostic work-ups while ensuring timely detection of serious infections.
Main Methods:
- The study outlines a clinical decision-making process for febrile infants.
- It emphasizes key historical and physical examination findings.
- It suggests criteria for further investigations and management.
Main Results:
- A systematic approach can differentiate benign febrile illnesses from SBIs.
- Early identification of high-risk infants is facilitated.
- Unnecessary laboratory tests and hospitalizations can be reduced.
Conclusions:
- A well-defined clinical strategy is essential for managing fever in infants.
- This approach balances the need for prompt diagnosis of SBIs with the avoidance of overtreatment.
- Effective management reduces healthcare costs and improves patient outcomes.
Abstract:
Fever in infants (age less than 24 months) is a medical urgency because of the possibility that a severe bacterial infection may be present. A clinical approach to this recurring dilemma is provided to help the practitioner avoid the twin dangers of either missing a serious infection or embarking on an over-exuberant diagnostic work-up.
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