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Related Experiment Videos

Septicemia in children with leukemia.

Y DeClerck, D DeClerck, G E Rivard

    Canadian Medical Association Journal
    |June 24, 1978
    PubMed
    Summary

    In pediatric leukemia patients, gram-positive bacteria caused septicemia as often as gram-negative bacteria but were less fatal. Early antibiotic choices should consider gram-positive pathogens.

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    Area of Science:

    • Pediatric Oncology
    • Infectious Diseases
    • Hematology

    Background:

    • Septicemia is a serious complication in children with leukemia.
    • Identifying causative agents and their impact is crucial for treatment.

    Purpose of the Study:

    • To analyze the epidemiology and outcomes of septicemia in pediatric leukemia patients.
    • To compare the clinical significance of gram-positive versus gram-negative bacterial infections.

    Main Methods:

    • Retrospective review of hospital records for 164 children with leukemia diagnosed between 1969 and 1975.
    • Analysis of 51 septicemia episodes and 57 isolated infectious agents.
    • Comparison of mortality, duration of neutropenia, and time to diagnosis based on bacterial type.

    Main Results:

    • Gram-positive and gram-negative bacteria were equally frequent causes of septicemia.
    • Gram-negative septicemia had a significantly higher fatality rate (9/23) than gram-positive (2/24).
    • Patients with gram-negative septicemia experienced longer neutropenia (19.5 days vs. 5.6 days) and diagnosis delays (29.0 days vs. 5.9 days).

    Conclusions:

    • Gram-positive bacteria are significant pathogens in pediatric leukemia patients with septicemia.
    • Initial antibiotic therapy should include coverage for gram-positive organisms.
    • Understanding these differences can improve patient outcomes and guide treatment strategies.

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