Action of drugs on liposomes with varying charges

The effects of 12 amphipathic compounds--such as aromatic and aliphatic carboxylic acids, amines, imines, nitrogen-substituted derivatives, and aldehydes--on multilamellar liposomes with varying charges were monitored in biological systems. The stabilization-lysis action of amphipathic compounds on liposomes was influenced by either the electrostatic repulsion or the attraction force between these compounds and liposomes.