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Wrinkled DNA.

S Arnott, R Chandrasekaran, L C Puigjaner

    Nucleic Acids Research
    |March 11, 1983
    PubMed
    Summary
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    Researchers discovered an unusual DNA structure in alternating purine-pyrimidine sequences. This altered conformation, with a dinucleotide repeat, may be recognized by regulatory proteins.

    Area of Science:

    • Molecular Biology
    • Structural Biology
    • Biochemistry

    Background:

    • Standard B DNA exhibits a mononucleotide repeat motif.
    • Polymer DNA structures can adopt non-canonical forms.
    • Alternating purine-pyrimidine sequences are common in genomes.

    Purpose of the Study:

    • To investigate the secondary structure of poly d(GC):poly d(GC) in microcrystallites.
    • To determine if observed structural perturbations are specific to poly d(GC):poly d(GC) or a broader phenomenon.

    Main Methods:

    • X-ray crystallography of oriented fibers of poly d(GC):poly d(GC).
    • Analysis of secondary structure and nucleotide conformations.
    • Comparison with other alternating purine-pyrimidine DNA forms (D forms).

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    Main Results:

    • Poly d(GC):poly d(GC) in B form exhibits a dinucleotide repeat motif, not a mononucleotide repeat.
    • Alternate CpG nucleotides show altered C3'-O3' conformation, affecting phosphate group orientation.
    • Similar perturbations were observed in D forms of poly d(IC):poly d(IC) and poly d(AT):poly d(AT).

    Conclusions:

    • The observed structural perturbations are intrinsic to alternating purine-pyrimidine DNA sequences.
    • This unique DNA conformation may be recognized by regulatory proteins for sequence-specific binding.