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Modular structural units, exons, and function in chicken lysozyme.

M Go

    Proceedings of the National Academy of Sciences of the United States of America
    |April 1, 1983
    PubMed
    Summary
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    Chicken egg white lysozyme exhibits five compact structural units, termed modules, which align with gene exons. This supports the "proteins in pieces" concept, linking to "genes in pieces" and evolutionary origins.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Exon-intron structure of genes.
    • Protein structural units and their relation to gene organization.
    • Previous identification of structural units in hemoglobin.

    Purpose of the Study:

    • To identify compact structural units in chicken egg white lysozyme using an exon-mapping algorithm.
    • To investigate the correspondence between these structural units and the lysozyme gene's exons.
    • To explore the evolutionary implications of the observed structure-gene relationship.

    Main Methods:

    • Application of a previously developed algorithm for identifying compact structural units.
    • Analysis of chicken egg white lysozyme structure.

    Related Experiment Videos

  • Comparison of identified structural units with lysozyme gene exon boundaries.

    • Main Results:

    • Identification of five distinct modules (M1-M5) in chicken egg white lysozyme.
    • Strong correlation between these modules and the exons of the lysozyme gene.
    • Localization of catalytic sites (glutamic acid-35, aspartic acid-52) within module M2, suggesting functional significance.

    Conclusions:

    • The identified modules in lysozyme correspond well to its exons, reinforcing the "proteins in pieces" hypothesis.
    • This structural-gene correspondence supports the evolutionary concept of "genes in pieces."
    • The findings provide insights into the evolutionary origin of introns in proteins like lysozyme and globins.