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Bone scan in sickle cell crisis.

A Sain, R Sham, L Silver

    Clinical Nuclear Medicine
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Technetium-99m diphosphonate bone scans reveal common abnormalities in patients with sickle cell disease during acute crisis, particularly in joints and the skull. Splenic uptake was also observed in some patients, regardless of splenic calcification.

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    Area of Science:

    • Nuclear medicine
    • Hematology
    • Radiology

    Background:

    • Sickle cell disease is a genetic blood disorder characterized by abnormal hemoglobin.
    • Acute sickle crisis can lead to various complications, including bone and organ damage.
    • Bone scintigraphy is a diagnostic imaging technique used to evaluate bone metabolism and detect abnormalities.

    Purpose of the Study:

    • To analyze the findings of 99mTc-diphosphonate bone scans in patients experiencing acute sickle crisis.
    • To investigate the prevalence and patterns of abnormal radiotracer uptake in sickle cell patients.
    • To discuss the pathophysiology and utility of bone scanning in managing sickle cell disease.

    Main Methods:

    • Retrospective analysis of 99mTc-diphosphonate bone scans from 13 patients with acute sickle crisis.

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  • Evaluation of scan findings, including areas of increased (hot) and decreased (cold) activity.
  • Correlation of scan results with clinical presentation and splenic calcification status.

    • Main Results:

    • Twelve out of 13 patients (92%) exhibited abnormal bone scan findings.
    • Common abnormalities included increased radiotracer uptake in joints and the skull.
    • Splenic uptake of diphosphonate was noted in three patients, irrespective of splenic calcification.
    • Most abnormal scans showed hyperfixation (hot areas); cold areas were less frequent (four cases).
    • No significant correlation was found between the location of clinical pain and abnormal scan findings.

    Conclusions:

    • 99mTc-diphosphonate bone scintigraphy frequently reveals abnormalities in patients with sickle cell disease during acute crisis.
    • Bone scans can identify joint and skull involvement, as well as splenic uptake, which may not always correlate with clinical symptoms.
    • The study highlights the potential role of bone scanning in understanding the pathophysiology and complications of sickle cell disease.