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Serum ferritin level in infants and children with anaemia and malignant disease
Insights
Serum ferritin testing in young children revealed low levels in 13% post-hospitalization. This iron status marker helps distinguish iron deficiency from infectious anemia and is elevated in pediatric cancers.
Area of Science:
- Pediatric Hematology
- Clinical Biochemistry
- Oncology
Background:
- Serum ferritin levels are crucial indicators of iron status and inflammation in children.
- Accurate assessment is vital for diagnosing anemia and monitoring disease progression.
- Distinguishing between iron deficiency anemia and anemia of chronic disease/infection can be challenging.
Purpose of the Study:
- To evaluate serum ferritin levels in hospitalized children aged 6 months to 3 years.
- To assess the utility of serum ferritin in differentiating iron deficiency from infectious anemia.
- To investigate serum ferritin concentrations in children with malignant diseases.
Main Methods:
- Immunoradiometry was used to determine serum ferritin levels.
- Measurements were taken in children immediately prior to hospital discharge.
- Patient groups included those treated for acute non-hematological diseases and those with malignant conditions.
Main Results:
- 13% of children exhibited low serum ferritin values.
- Serum ferritin concentration proved sensitive in differentiating iron deficiency from infectious anemia.
- Children with malignant diseases (leukemia, solid tumors) showed significantly higher mean serum ferritin levels.
Conclusions:
- Serum ferritin is a valuable biomarker in pediatric populations.
- It aids in the differential diagnosis of anemia in young children.
- Elevated serum ferritin may indicate underlying malignant processes in children.
Abstract:
Serum ferritin was determined by immunoradiometry in children aged 6 months to 3 years, immediately before leaving hospital where they had been treated for various acute, non-haematological diseases. A low value was found in 13% of them. Serum ferritin concentration is a sensitive method in differentiating between iron deficiency and infectious anaemia. A significantly higher mean value was found in children affected by malignant disease (acute lymphoid or myeloid leukaemia, various solid tumours).