Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dubowitz syndrome and acute lymphatic leukemia].

H Gröbe

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |July 1, 1983
    PubMed
    Summary

    Children with Dubowitz syndrome face an increased risk of developing acute lymphatic leukemia. This rare genetic disorder may predispose individuals to certain cancers, necessitating further research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The work of the Cochrane Collaboration in urology].

    Der Urologe. Ausg. A·2011
    Same author

    Influence of Sleeve Gastrectomy on NASH and Type 2 Diabetes Mellitus.

    Journal of obesity·2011
    Same author

    Metabolic control as reflected by HbA1c in children, adolescents and young adults with type-1 diabetes mellitus: combined longitudinal analysis including 27,035 patients from 207 centers in Germany and Austria during the last decade.

    European journal of pediatrics·2007
    Same author

    Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency.

    Journal of inherited metabolic disease·2004
    Same author

    Scientific data must be made available to all.

    Nature·2001
    Same author

    [Townes-Brocks syndrome. Case report and review of the literature].

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde·1992

    Area of Science:

    • Pediatric Oncology
    • Clinical Genetics
    • Hematology

    Background:

    • Dubowitz syndrome is a rare genetic disorder characterized by specific physical features and developmental delays.
    • Malignancies are not typically considered a primary feature of Dubowitz syndrome, but case reports are emerging.
    • Understanding the genetic underpinnings of Dubowitz syndrome may shed light on cancer predisposition.

    Observation:

    • A pediatric patient diagnosed with Dubowitz syndrome presented with acute lymphatic leukemia at 6.75 years of age.
    • The leukemia was refractory to standard, intensive chemotherapy regimens.
    • No remission was achieved despite appropriate therapeutic interventions.

    Findings:

    • The case suggests a potential link between Dubowitz syndrome and an elevated risk of developing acute lymphatic leukemia.
    • The aggressive nature of the leukemia in this patient highlights potential unique biological characteristics.
    • Treatment resistance in this context warrants further investigation into underlying mechanisms.

    Implications:

    • This case underscores the importance of vigilant cancer surveillance in individuals with Dubowitz syndrome.
    • Further research is needed to elucidate the specific mechanisms conferring malignancy risk in Dubowitz syndrome.
    • Genetic counseling and long-term monitoring protocols may need to be adapted for affected individuals.

    Related Experiment Videos