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Neuropeptides and thirst.

M D Evered

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Several neuropeptides influence fluid intake in vertebrates. Angiotensin II, a key hormone, consistently stimulates drinking across species and may act as a neurotransmitter in the central nervous system.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Comparative Physiology

    Background:

    • Neuropeptides are known to influence fluid intake in vertebrates.
    • The specific mechanisms and sites of action for most neuropeptides affecting thirst are poorly understood.
    • Angiotensin II is a well-characterized peptide hormone involved in blood volume and pressure regulation.

    Purpose of the Study:

    • To review the known effects of various neuropeptides on fluid intake in different vertebrate species.
    • To highlight the role of angiotensin II in stimulating drinking behavior.
    • To explore the potential neurotransmitter or neuromodulator functions of angiotensin II within the central nervous system.

    Main Methods:

    • Review of existing literature on neuropeptide effects on fluid intake.

    Related Experiment Videos

  • Analysis of studies involving direct brain injections of neuropeptides in various vertebrate models.
  • Examination of evidence for central nervous system synthesis of angiotensin II.

    • Main Results:

    • Multiple neuropeptides, including tachykinins, opioids, bombesin, neurotensin, and vasopressin, affect fluid intake.
    • Angiotensin II consistently stimulates drinking behavior when administered intravenously or intracranially across reptiles, birds, and mammals.
    • Evidence suggests angiotensin II possesses the necessary components for synthesis within the central nervous system.

    Conclusions:

    • Angiotensin II plays a significant role in regulating fluid intake and drinking behavior across diverse vertebrate species.
    • The presence of synthesis machinery in the central nervous system supports a potential neuromodulatory or neurotransmitter role for angiotensin II in thirst regulation.
    • Further research is needed to elucidate the precise mechanisms and physiological relevance of various neuropeptides in controlling fluid balance.