Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subcortical projections from ectopic neocortical neurons.

K F Jensen, H P Killackey

    Proceedings of the National Academy of Sciences of the United States of America
    |February 1, 1984
    PubMed
    Summary

    Ionizing radiation disrupts corticospinal neuron development, causing abnormal locations. Early embryonic irradiation before embryonic day 17 leads to periventricular ectopias, indicating early projection determination.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cost of illness of HER2-positive and metastatic and recurrent HER2-positive breast cancer - a Danish register-based study from 2005 to 2016.

    BMC health services research·2022
    Same author

    Effects of ozone and acidic fog on red spruce needle epicuticular wax production, chemical composition, cuticular membrane ultrastructure and needle wettability.

    The New phytologist·2021
    Same author

    Static and dynamic aspects of cortical somatotopy: a critical evaluation.

    Journal of cognitive neuroscience·2013
    Same author

    Neocortical Expansion: An Attempt toward Relating Phylogeny and Ontogeny.

    Journal of cognitive neuroscience·2013
    Same author

    Microfluidic jet injection for delivering macromolecules into cells.

    Journal of micromechanics and microengineering : structures, devices, and systems·2013
    Same author

    Selective silver staining for neural degeneration.

    Methods in molecular medicine·2011

    Area of Science:

    • Neuroscience
    • Developmental Neuroscience
    • Cortical Development

    Background:

    • The cerebral cortex exhibits specific efferent connections.
    • Corticospinal neurons in rodent neocortical layer V are present at birth but undergo areal distribution changes.
    • Neocortical development can be disrupted by ionizing radiation during neuronal production.

    Purpose of the Study:

    • To investigate the impact of ionizing radiation on corticospinal neuron location and projection specificity.
    • To determine if migratory path or final position is essential for subcortical target specification.
    • To ascertain the critical developmental window for determining corticospinal neuron projections.

    Main Methods:

    • Disruption of rodent neocortical development using ionizing radiation at various embryonic stages.
    • Analysis of the location of corticospinal neurons in adult rats post-irradiation.
    • Tracing of neuronal projections to assess subcortical target specificity.

    Main Results:

    • Irradiation before, during, or after layer V neuron production resulted in abnormally located corticospinal neurons.
    • Periventricular ectopias of corticospinal neurons were observed in rats irradiated on or before embryonic day 17.
    • Scattered supragranular corticospinal neurons were found in rats irradiated on embryonic days 16-19.
    • Neurons in abnormal locations projected to appropriate subcortical targets, irrespective of position.

    Conclusions:

    • Neuronal migratory path and final position are not essential for specifying subcortical targets.
    • Early embryonic irradiation (on or before embryonic day 17) influences the determination of corticospinal neuron projections.
    • Initial projections of corticospinal neurons are determined early in ontogeny, prior to migration.

    Related Experiment Videos