Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chaotic behavior in dopamine neurodynamics.

R King, J D Barchas, B A Huberman

    Proceedings of the National Academy of Sciences of the United States of America
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA<sub>A</sub> receptors.

    Translational psychiatry·2019
    Same author

    Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations.

    Brain structure & function·2017
    Same author

    Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder.

    Translational psychiatry·2016
    Same author

    Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder.

    Translational psychiatry·2015
    Same author

    Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.

    Molecular psychiatry·2014
    Same author

    The effects of alcohol on cyclic AMP in mouse brain.

    Neurochemical research·2013
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    This study reveals that dopamine receptor efficacy (k) can trigger chaotic dynamics in neuronal models. These findings may explain behavioral variability in schizophrenia and Parkinson's disease.

    Area of Science:

    • Neuroscience
    • Computational Biology
    • Dynamical Systems Theory

    Background:

    • The central dopaminergic system plays a crucial role in motor control, mood, and cognition.
    • Aberrant dopaminergic activity is implicated in various neurological and psychiatric disorders, including schizophrenia, Parkinson's disease, and affective disorders.
    • Understanding the complex dynamics of this system is essential for elucidating disease mechanisms.

    Purpose of the Study:

    • To investigate the dynamical behavior of a computational model of the central dopaminergic neuronal system.
    • To explore the relationship between dopamine receptor efficacy and the emergence of chaotic solutions.
    • To correlate model predictions with observed clinical symptoms in neurological and psychiatric conditions.

    Main Methods:

    Related Experiment Videos

    • Development and analysis of a mathematical model for central dopaminergic neuronal dynamics.
    • Simulation of the model under varying parameters, specifically dopamine receptor efficacy (k).
    • Identification and characterization of chaotic regimes within the model's phase space.

    Main Results:

    • Chaotic solutions emerge in the dopaminergic neuronal model for specific values of the dopamine receptor efficacy parameter (k).
    • The appearance or disappearance of erratic solutions is dependent on both the parameter k and the external input to the system.
    • These findings provide a potential dynamical explanation for behavioral variability in schizophrenia, motor fluctuations in Parkinson's disease, and mood lability in affective disorders.

    Conclusions:

    • Dopamine receptor efficacy is a critical factor influencing the stability and dynamics of the central dopaminergic system.
    • The emergence of chaos in this system offers a plausible mechanism underlying complex behavioral symptoms observed in neurological and psychiatric conditions.
    • The model provides testable hypotheses regarding the role of dopamine signaling dynamics in disease pathophysiology.