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Cell adhesion and morphogenesis: the regulator hypothesis.

G M Edelman

    Proceedings of the National Academy of Sciences of the United States of America
    |March 1, 1984
    PubMed
    Summary
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    The regulator hypothesis proposes that cell adhesion molecules (CAMs) guide early development, influencing evolution. Natural selection favors stable gene expression patterns, shaping animal form over time.

    Area of Science:

    • Developmental biology
    • Evolutionary genetics
    • Molecular biology

    Background:

    • Morphogenesis involves complex genetic and molecular regulation.
    • Cell adhesion molecules (CAMs) play crucial roles in embryonic development.
    • Understanding the interplay between gene expression and morphogenetic movements is key.

    Purpose of the Study:

    • To propose the regulator hypothesis, a molecular framework linking developmental genetics and evolution.
    • To explain the roles of cell adhesion molecules (CAMs) in regulating morphogenetic processes.
    • To explore how natural selection acts on variations in CAM gene expression and morphogenetic movements.

    Main Methods:

    • Analysis of interactive morphogenetic roles of cell adhesion, cell movement, and embryonic induction.

    Related Experiment Videos

  • Review of experimental evidence for the regulator hypothesis, focusing on CAM molecular properties and spatio-temporal expression.
  • Theoretical modeling of evolutionary implications of CAM gene regulation.

    • Main Results:

    • The regulator hypothesis posits that CAM gene expression precedes and influences cytodifferentiation.
    • Expressed CAMs regulate morphogenetic movements essential for inductive sequences.
    • Natural selection acts against disruptions in inductive sequences caused by CAM gene expression or morphogenetic variations.

    Conclusions:

    • The regulator hypothesis provides a molecular basis for understanding evolutionary changes in animal form.
    • Stabilization of inductive sequences and body plans is achieved through selection on CAM gene regulation.
    • Minor variations in CAM gene regulation can drive significant evolutionary changes in morphology.