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Mitochondrial gene flow.

N Takahata, M Slatkin

    Proceedings of the National Academy of Sciences of the United States of America
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Mitochondrial DNA transmission between Drosophila species can occur readily, even across species boundaries. This gene flow, driven by population genetics, influences nuclear genome divergence over time.

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    Area of Science:

    • Evolutionary biology
    • Population genetics
    • Molecular evolution

    Background:

    • Mitochondrial DNA (mtDNA) transmission between species, known as cytoplasmic introgression, has been observed in closely related species like Drosophila pseudoobscura and D. persimilis.
    • Understanding the genetic mechanisms facilitating or hindering mtDNA transmission is crucial for evolutionary studies.

    Purpose of the Study:

    • To model the transmission of mitochondrial DNA between conspecific species.
    • To investigate the influence of selection and gene flow on mtDNA transmission.
    • To reexamine nuclear genome divergence in light of potential mitochondrial gene flow.

    Main Methods:

    • Analysis of a simple population genetics model with two alleles at two loci (autosomal and mitochondrial).
    • Inclusion of viability selection (underdominant at autosomal locus, neutral/deleterious at mitochondrial locus).

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  • Multiplicative action of selection and gene flow in infinite populations.

    • Main Results:

    • Mitochondrial DNA transmission between species can occur easily unless there is extremely strong selection against heterozygotes.
    • The rate of reaching genetic equilibrium is primarily determined by gene flow levels.
    • Selection at the autosomal locus has minimal impact on the rate of equilibrium attainment.
    • Evidence suggests prolonged mitochondrial gene flow between D. pseudoobscura and D. persimilis.

    Conclusions:

    • Mitochondrial gene flow can readily occur between closely related species.
    • The divergence observed in nuclear genomes may be a consequence of accumulated neutral mutations facilitated by long-term mitochondrial gene flow.
    • Selection against heterozygotes plays a critical role in determining the extent of interspecific mtDNA transmission.