Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet imipramine binding in autistic subjects.

G M Anderson, R B Minderaa, P P van Benthem

    Psychiatry Research
    |February 1, 1984
    PubMed
    Summary

    This study found no differences in serotonin transporter regulation in autistic individuals, suggesting that altered serotonin uptake is not a key factor in autism. This research provides insights into the neurobiology of autism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Role of the serotonin transporter gene in the behavioral expression of autism.

    Molecular psychiatry·2001
    Same author

    Mothers' functioning and children's symptoms 5 years after a SCUD missile attack.

    The American journal of psychiatry·2001
    Same author

    A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.

    The American journal of psychiatry·2001
    Same author

    3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.

    The New England journal of medicine·2001
    Same author

    Effect of eptifibatide on coronary flow reserve following coronary stent implantation (an ESPRIT substudy). Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy.

    The American journal of cardiology·2001

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Autism Spectrum Disorder Research

    Background:

    • Previous studies indicated elevated platelet serotonin (5-HT) in autistic individuals.
    • This suggested potential alterations in platelet 5-HT uptake mechanisms in autism.

    Purpose of the Study:

    • To investigate whether 5-HT uptake is altered in autism.
    • To compare the parameters of 3H-imipramine (IMI) binding in autistic subjects and normal volunteers.

    Main Methods:

    • Measured 3H-imipramine (IMI) binding parameters (Bmax and Kd) in drug-free autistic subjects (n=11) and normal volunteers (n=10).
    • Analyzed the number and affinity of IMI binding sites.

    Main Results:

    • No significant differences were found in the mean Bmax (maximal binding capacity) between autistic subjects (1350 +/- fmole/mg protein) and normal volunteers (1590 +/- 206 fmole/mg protein).

    Related Experiment Videos

  • Similarly, no significant differences were observed in the mean Kd (dissociation constant, indicating binding affinity) between groups (autistics: 0.98 +/- 0.10 nM; normals: 0.94 +/- 0.13 nM).

    • Conclusions:

    • The findings suggest that the number and affinity of the IMI binding site, reflecting serotonin transporter regulation, are not different in autism.
    • This indicates that altered serotonin uptake regulation is unlikely to be a primary factor contributing to autism.