Uterine hyperstimulation and rupture after induction of labour with prostaglandin E2. Case reports

Three patients are described in whom hyperstimulation of the uterus followed induction of labour with prostaglandin E2 tablets administered either orally or vaginally. All 3 patients were grand multiparas. Two patients sustained a ruptured uterus. It is concluded that the dangers of inducing labour in grand multiparas by means of this technique are no less than those associated with amniotomy and infusion of oxytocin. Recommendations concerning dosage schedules are made.