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Human transferrin: cDNA characterization and chromosomal localization.

F Yang, J B Lum, J R McGill

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1984
    PubMed
    Summary
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    This study identified the transferrin (Tf) gene

    Area of Science:

    • Molecular Biology
    • Genetics
    • Biochemistry

    Background:

    • Transferrin (Tf) is the primary serum iron-binding protein in vertebrates.
    • Tf shares sequence homology with lactotransferrin, ovotransferrin, melanoma antigen p97, and HuBlym-1.
    • The Tf receptor and melanoma p97 genes are located on human chromosome 3.

    Purpose of the Study:

    • To characterize the human transferrin (Tf) gene.
    • To identify and analyze the Tf cDNA sequence.
    • To map the chromosomal location of the Tf gene.

    Main Methods:

    • Screening an adult human liver cDNA library using a mixed oligonucleotide probe.
    • Analysis of the 2.3 kilobase pair Tf cDNA sequence.
    • Chromosomal mapping via in situ hybridization and somatic cell hybrid analysis.

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    Main Results:

    • Isolation of recombinant plasmids containing human Tf cDNA.
    • Identification of a probable leader sequence and homologous amino/carboxyl domains within the Tf cDNA.
    • Localization of the Tf gene to human chromosome 3, region q21-25.

    Conclusions:

    • The human Tf gene has been characterized, including its cDNA sequence.
    • Conserved regions in Tf domains suggest functional importance in iron binding.
    • The Tf gene's location on chromosome 3 supports its linkage with the Tf receptor and melanoma p97 loci.