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The patas monkey as a model for dihydrostreptomycin ototoxicity.
Acta Oto-Laryngologica
|January 1, 1977
Summary
Dihydrostreptomycin (DHSM) causes hearing loss in patas monkeys, unlike M. nemestrina monkeys. This finding highlights the patas monkey as a potential animal model for studying aminoglycoside ototoxicity.
Area of Science:
- Ototoxicology
- Pharmacology
- Primate Models
Background:
- Dihydrostreptomycin (DHSM) is known to cause cochlear toxicity in humans.
- Demonstrating DHSM-induced ototoxicity in animal models has historically been challenging.
Purpose of the Study:
- To investigate the ototoxicity of dihydrostreptomycin (DHSM) in different primate species.
- To identify a suitable animal model for evaluating aminoglycoside ototoxicity.
Main Methods:
- Administered DHSM (100 mg/kg daily for 8 months) to M. nemestrina monkeys.
- Administered DHSM (20 mg/kg daily for 90 days) to E. patas monkeys.
- Monitored hearing thresholds in both primate groups.
Main Results:
- M. nemestrina monkeys showed no significant changes in hearing thresholds.
- E. patas monkeys exhibited severe deafness after DHSM treatment.
- The dosage and duration in E. patas monkeys mimicked a human tuberculosis treatment regimen.
Conclusions:
- E. patas monkeys are susceptible to DHSM-induced ototoxicity.
- The patas monkey model may be valuable for assessing aminoglycoside ototoxicity.
- This study provides a potential animal model for understanding drug-induced hearing loss.