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Iohexol and metrizamide for urography in infants and children

G Stake, B Smevik

    Acta Radiologica. Supplementum
    |January 1, 1983
    PubMed

    Insights

    Iohexol, a new non-ionic contrast medium, showed negligible adverse reactions and comparable diagnostic quality to metrizamide in pediatric urography. Both agents caused a slight decrease in hematocrit values.

    Area of Science:

    • Radiology
    • Pediatric Imaging
    • Contrast Media

    Background:

    • Contrast media are essential for diagnostic imaging in children.
    • Non-ionic contrast agents are preferred for their safety profile.
    • Iohexol is a newer non-ionic agent requiring evaluation.

    Purpose of the Study:

    • To compare the safety and efficacy of iohexol versus metrizamide in pediatric urography.
    • To assess adverse reactions and diagnostic image quality.

    Main Methods:

    • Double-blind investigation involving 40 children under 6 years of age.
    • Administration of iohexol or metrizamide for urography.
    • Monitoring for adverse events and evaluating film quality.

    Main Results:

    • Negligible adverse reactions observed with both contrast media.
    • A small, transient decrease in erythrocyte volume fraction (hematocrit) noted in both groups.
    • Excellent diagnostic image quality achieved, with no significant difference between iohexol and metrizamide.

    Conclusions:

    • Iohexol is a safe and effective non-ionic contrast medium for pediatric urography.
    • It offers comparable diagnostic performance to metrizamide with minimal side effects.
    • Further use of iohexol in pediatric populations is warranted.

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