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Recent progress in improving data processing in filtration measurements.

P Teitel, H Malotta, M Leschke

    Biorheology. Supplement : the Official Journal of the International Society of Biorheology
    |January 1, 1984
    PubMed
    Summary
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    Nucleopore filter membranes show poor reproducibility for measuring red blood cell (RBC) deformability. A new statistical method identifies and removes aberrant data, improving measurement accuracy for RBC deformability.

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Materials Science

    Background:

    • Current methods for assessing red blood cell (RBC) deformability using Nucleopore filter membranes lack metrological rigor.
    • Inhomogeneities within these membranes introduce significant background noise, leading to poor measurement reproducibility.
    • Eliminating aberrant results from parallel measurements is crucial for reducing variance.

    Purpose of the Study:

    • To develop a reliable method for assessing RBC deformability.
    • To improve the reproducibility of RBC deformability measurements.
    • To introduce a procedure for identifying and excluding aberrant data points.

    Main Methods:

    • Utilized iterative statistical regression analysis for data analysis.
    • Calibrated filter membranes and performed measurements on RBC suspensions.

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  • Proposed a method to identify aberrant values in filter calibration and RBC suspension data.

    • Main Results:

    • Developed a procedure to identify aberrant values using statistical regression analysis.
    • Demonstrated that eliminating aberrant results enhances measurement reproducibility.
    • Results are expressed as "reduced" initial flow rates for standard filter resistance.

    Conclusions:

    • Nucleopore filter membranes are not ideal for precise RBC deformability measurements due to inherent inhomogeneities.
    • A proposed iterative statistical regression analysis effectively identifies aberrant data, improving measurement reliability.
    • The new method offers a more accurate assessment of RBC deformability by reducing experimental noise and variance.