Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haptoglobin groups and leukemia.

N Fröhlander

    Human Heredity
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Haptoglobin (Hp) typing in leukemia patients revealed no association with Hp1-1 or the Hp1 gene. However, a significant increase in ahaptoglobinemia (Hp0) was observed in leukemia patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.

    Developmental dynamics : an official publication of the American Association of Anatomists·1997
    Same author

    Haptoglobin-stimulated bone resorption in neonatal mouse calvarial bones in vitro.

    Arthritis and rheumatism·1992
    Same author

    Alkaline phosphatases as reporters of developmental and cancerous events.

    In vivo (Athens, Greece)·1991
    Same author

    Haptoglobin synergistically potentiates bradykinin and thrombin induced prostaglandin biosynthesis in isolated osteoblasts.

    Biochemical and biophysical research communications·1991
    Same author

    Heterozygosity effects in studies of genetic markers and disease.

    Human heredity·1990
    Same author

    Genetic variation of haptoglobin and transferrin in relation to DNA content and stage in renal cell carcinoma.

    Cancer·1989
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Area of Science:

    • Hematology
    • Genetics

    Background:

    • Haptoglobin (Hp) is a plasma protein involved in hemoglobin binding.
    • Previous studies suggested associations between specific Hp phenotypes and leukemia.
    • The clinical significance of Hp polymorphism in hematological malignancies requires further investigation.

    Purpose of the Study:

    • To investigate the distribution of haptoglobin (Hp) phenotypes in leukemia patients.
    • To examine potential associations between Hp groups and leukemia.
    • To confirm or refute previously reported links between Hp genotypes and leukemia risk.

    Main Methods:

    • Haptoglobin phenotyping was performed on 100 leukemia patients.
    • A control group was included for comparison.
    • Statistical analysis was used to compare Hp group frequencies between patients and controls.

    Related Experiment Videos

    Main Results:

    • No significant association was found between Hp1-1 phenotype and leukemia.
    • The Hp1 gene association with leukemia was not confirmed in this cohort.
    • A statistically significant increase in ahaptoglobinemia (Hp0) was observed in leukemia patients compared to controls.

    Conclusions:

    • Haptoglobin phenotyping in leukemia patients did not support previous findings regarding Hp1-1 or Hp1 gene associations.
    • The study confirms a higher prevalence of ahaptoglobinemia (Hp0) in leukemia patients.
    • Ahaptoglobinemia may serve as a potential biomarker in leukemia, warranting further research.