Penetration of cefotetan into serum, myometrium, endometrium and salpinges

24 patients received an intravenous 5-min bolus injection of 2 g cefotetan at various times prior to abdominal or vaginal hysterectomy. Cefotetan concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 16 micrograms/g could be attained for at least 5 h. At this concentration, 90% of most aerobic and anaerobic bacteria causing genital tract infections are inhibited.