Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stage-related decrease in natural killer cell activity in untreated patients with mycosis fungoides.

S Levy, J L Tempé, P Caussade

    Cancer Immunology, Immunotherapy : CII
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [150 years of Annales de dermatologie 1868-2018].

    Annales de dermatologie et de venereologie·2019
    Same author

    [Reactive perforating collagenosis].

    Annales de dermatologie et de venereologie·2012
    Same author

    [Chronically neglected malignant skin tumours].

    Annales de dermatologie et de venereologie·2012
    Same author

    [Annular elastolytic giant cell granuloma].

    Annales de dermatologie et de venereologie·2010
    Same author

    Trichoblastic carcinoma of the pinna. A rare case.

    Hippokratia·2009
    Same author

    [Artefacts in dermatopathology].

    Annales de dermatologie et de venereologie·2009
    Same journal

    Conserved minimal CD8 cytotoxic immune-state unit in an IL18R1-associated immune program in hepatocellular carcinoma.

    Cancer immunology, immunotherapy : CII·2026
    Same journal

    Safety and feasibility of 5T4 antibody-coupled allogeneic NK cell therapy for solid tumors: a first-in-human phase 1 trial.

    Cancer immunology, immunotherapy : CII·2026
    Same journal

    Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform.

    Cancer immunology, immunotherapy : CII·2026
    Same journal

    Correction: Repurposing public sarcoma multi-omics for neoantigen discovery.

    Cancer immunology, immunotherapy : CII·2026
    Same journal

    A low-dose self-amplifying mRNA vaccine encoding HPV16 E6/E7 induces potent T-cell immunity and antitumor protection in mice.

    Cancer immunology, immunotherapy : CII·2026
    Same journal

    GLP-1 receptor agonists at immune checkpoint inhibitor initiation with immune-related and supportive-care outcomes in patients with cancer and overweight or obesity without diabetes: a target trial emulation.

    Cancer immunology, immunotherapy : CII·2026
    See all related articles

    Natural killer cell activity is impaired in patients with advanced mycosis fungoides, a type of skin cancer. Early-stage patients showed normal activity, suggesting functional defects in advanced disease.

    Area of Science:

    • Immunology
    • Dermatology
    • Oncology

    Background:

    • Mycosis fungoides is a type of cutaneous T-cell lymphoma.
    • Natural killer (NK) cells play a crucial role in immune surveillance against cancer.
    • Assessing NK cell activity in mycosis fungoides can provide insights into disease pathogenesis and immune evasion strategies.

    Purpose of the Study:

    • To evaluate the natural killer activity of peripheral blood mononuclear cells (PBMCs) in patients with mycosis fungoides.
    • To compare NK cell activity between patients with early and advanced disease and age-matched controls.
    • To explore potential therapeutic implications by assessing the response to alpha-interferon.

    Main Methods:

    • Peripheral blood mononuclear cells (PBMCs) were isolated from 11 patients with mycosis fungoides and 10 healthy controls.

    Related Experiment Videos

  • NK cell activity was assessed using a standard chromium release assay against the K562 target cell line at various effector:target ratios.
  • One patient with low NK activity was preincubated with alpha-interferon to assess functional response.

    • Main Results:

    • Patients with early-stage mycosis fungoides exhibited normal NK cell activity, comparable to controls.
    • Patients with advanced mycosis fungoides demonstrated a significant defect in NK cell activity across multiple effector:target ratios.
    • Preincubation with alpha-interferon in a single patient suggested that the defect might be due to reduced functional capacity rather than cell depletion.

    Conclusions:

    • Advanced mycosis fungoides is associated with a significant impairment of natural killer cell activity.
    • The observed defect in NK cell function may contribute to disease progression and immune evasion.
    • Alpha-interferon may hold potential for restoring NK cell function in affected patients.