The pharmacokinetics and tissue penetration of ofloxacin

The pharmacokinetics of the 4-quinolone agent, ofloxacin, were studied in six healthy volunteers, following a 600 mg oral dose. The levels of the compound were measured by a microbiological assay in serum, blister fluid and urine. The compound was rapidly absorbed, the mean maximum concentration of ofloxacin being 10.7 mg/l at 1.2 h. The mean serum elimination half-life was 7 h and 80.3% of the administered compound was recovered in the urine by 48 h. Ofloxacin penetrated the blister fluid well, the mean peak level being 5.2 mg/l at 5.3 h.