Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A test of nonrandom segregation.

J A Badner, A Chakravarti, D K Wagener

    Genetic Epidemiology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a statistical test for nonrandom segregation of marker genes, crucial for understanding disease associations. Evidence suggests a leprosy susceptibility gene is located near the HLA locus on chromosome 6.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systematic Implementation of Effective Quality Assurance Processes for the Assessment of Radiation Target Volumes in Head and Neck Cancer.

    Practical radiation oncology·2024
    Same author

    Pulse parameter optimizer: an efficient tool for achieving prescribed dose and dose rate with electron FLASH platforms.

    Physics in medicine and biology·2023
    Same author

    Prognostic Significance of IDH1/2 Mutation and MGMT Promoter Methylation Status in RTOG 9813.

    International journal of radiation oncology, biology, physics·2021
    Same author

    MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2018
    Same author

    Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.

    Oncogene·2017
    Same author

    On the Choice of Drugs in the Treatment of Bacterial Infections.

    The Indian medical gazette·2017

    Area of Science:

    • Genetics
    • Statistical genetics
    • Human genetics

    Background:

    • Disease associations within families are often detected by observing nonrandom segregation of marker alleles in affected offspring.
    • Nonrandom segregation can result from genetic linkage, epistatic gene action, or segregation distortion at the marker locus.

    Purpose of the Study:

    • To develop and analyze a general statistical test for nonrandom segregation of marker genes.
    • To derive the probability distributions under null (random segregation) and alternative (genetic linkage) hypotheses.
    • To provide methods for calculating significance values and assessing the adequacy of random segregation models.

    Main Methods:

    • Derivation of exact probability distributions for the nonrandom segregation test under null and alternative hypotheses.

    Related Experiment Videos

  • Computation of mean and variance for these distributions.
  • Application of the methods to study HLA segregation in families with tuberculoid leprosy.

    • Main Results:

    • The study provides a method for computing exact significance values under the null hypothesis of random segregation.
    • Analysis of families with tuberculoid leprosy suggests a gene controlling susceptibility to Mycobacterium leprae infection.
    • This susceptibility gene is located on human chromosome 6, approximately 13 map units from the HLA locus in males.

    Conclusions:

    • The developed statistical methods are effective for analyzing disease-marker associations and genetic linkage.
    • Evidence supports the localization of a leprosy susceptibility gene near the HLA locus on chromosome 6.
    • This finding contributes to understanding the genetic basis of tuberculoid leprosy and its association with the human leukocyte antigen (HLA) system.