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Related Experiment Videos

Trimethoprim-sulfamethoxazole.

F R Cockerill, R S Edson

    Mayo Clinic Proceedings
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Trimethoprim-sulfamethoxazole is an effective antimicrobial for various bacterial infections, including genitourinary, respiratory, and gastrointestinal tracts. Dosage adjustment is necessary for patients with reduced kidney function.

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    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Microbiology

    Background:

    • Trimethoprim-sulfamethoxazole is a widely used antimicrobial combination.
    • It exhibits in vitro activity against a broad spectrum of bacteria.
    • Clinical applications include treatment and prophylaxis of various infections.

    Purpose of the Study:

    • To review the clinical utility and pharmacokinetic properties of trimethoprim-sulfamethoxazole.
    • To highlight its efficacy in specific infections like Nocardia asteroides and Pneumocystis carinii pneumonia.
    • To provide guidance on dosage adjustments in renal impairment.

    Main Methods:

    • Literature review of clinical studies and pharmacokinetic data.
    • Analysis of in vitro antimicrobial activity.

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  • Evaluation of treatment outcomes for various infections.

    • Main Results:

    • Effective against gram-positive and gram-negative bacteria.
    • Demonstrates significant efficacy in genitourinary, respiratory, and gastrointestinal infections.
    • Considered the drug of choice for Pneumocystis carinii pneumonia and effective for Nocardia asteroides infections.

    Conclusions:

    • Trimethoprim-sulfamethoxazole is a versatile and relatively non-toxic antimicrobial agent.
    • Available in oral and intravenous formulations for flexible administration.
    • Dosage requires adjustment in patients with creatinine clearance below 30 ml/min due to renal excretion.